disodium dihydrogen (1-hydroxyethylidene)diphosphonate
disodium ethydronate
CAS: 7414-83-7
Molecular Formula: C2H9NaO7P2
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Names and Identifiers
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Physico-chemical Properties
| Molecular Formula | C2H9NaO7P2 |
| Molar Mass | 230.02 |
| Melting Point | >300°C |
| Boling Point | 578.8°C at 760 mmHg |
| Water Solubility | Soluble in water (26 mg/ml). |
| Solubility | Easily soluble in water and ethanol, strong hygroscopicity. Acid and alkali resistance, chlorine oxidation resistance is better than other organic phosphonic acids (salts) |
| Appearance | White crystalline powder |
| Color | white |
| Merck | 14,3863 |
| Storage Condition | 15-25°C |
| MDL | MFCD00152567 |
| Use | Bone resorption inhibitors for primary osteoporosis and Postmenopausal Osteoporosis |
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 1 |
| RTECS | SZ8562240 |
| TSCA | Yes |
| HS Code | 29319090 |
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Reference
| Reference Show more | 1. GE Jing, Ling Jie, Ning Qing, et al. Evaluation of metabolism-effect/toxicity of epimedium arctii based on zebrafish M-Act/Tox [J]. Chinese herbal medicine, 2019, v.50;No.642(07):115-121. 2. Tian Tao, Fu Qiang, Zhu Jiankui, et al. Benefit observation of Erzhi pill in the treatment of zebrafish osteoporosis model and the mechanism of osteoclast autophagy [J]. Journal of Nanjing University of Traditional Chinese Medicine 2020 v.36(03):78-83. 3. Liu et al Wen-jin [IF = 4.36].. "J Ethnopharmacol. 2020 Jul;257:112871 |
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Nature
Open Data Verified Data
white powder. The melting point was 198-199 °c. Soluble in water and ethanol, strong hygroscopicity. Acid and alkali resistance, chlorine oxidation resistance than other organic phosphonic acid (salt) good. At high pH value is still very stable, not easy to hydrolysis, general light and heat conditions are not easy to decompose. It can form a six ring chelate with metal ions in water, especially calcium ions, so it has good scale inhibition effect and obvious solubility limit effect. When used in combination with other water treatment agents, show the ideal synergistic effect.
Last Update：2024-01-02 23:10:35
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Preparation Method
Open Data Verified Data
obtained by neutralization with hydroxy ethylene diphosphate and aqueous sodium hydroxide solution and spray drying.
Last Update：2022-01-01 09:28:53
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Standard
Authoritative Data Verified Data
This product is (1-hydroxyethylidene) disodium diphosphonate. The content of C2H6Na207P2 shall not be less than 98.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Trait
Authoritative Data Verified Data
- This product is white powder; Odorless, slightly salty; With hygroscopicity.
- This product is soluble in water, and almost insoluble in methanol, anhydrous ethanol, chloroform or ethanol.
Last Update：2022-01-01 13:36:40
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Use
Open Data Verified Data
is an organic phosphonic acid scale and corrosion inhibitor, can form stable complexes with iron, copper, zinc and other metal ions, can dissolve the metal surface oxides. At 250 deg C can still play a good effect of corrosion and scale inhibition. Widely used in electric power, chemical industry, metallurgy, chemical fertilizer and other industrial circulating cooling water systems and medium and low pressure boilers, oil field water injection and oil pipeline scale and corrosion inhibition; In circulating cooling water, oil field water injection, boiler Water treatment can be combined with sodium molybdate, silicate, zinc salt and copolymer. In the textile industry, it can be used as cleaning agents for metals and non-metals, peroxide stabilizers and fixing agents for bleaching and dyeing industry, and complexing agents for cyanide-free electroplating industry.
Last Update：2022-01-01 09:28:53
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Differential diagnosis
Authoritative Data Verified Data
- take about 0.2g of this product, add 20ml of water, shake to dissolve, add 1 ml of copper sulfate test solution, shake well, and place for 10 minutes to produce blue precipitate.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1158).
- identification reaction of sodium salt of this product (General rule 0301).
Last Update：2022-01-01 13:36:40
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Safety
Open Data Verified Data
is weakly acidic, should avoid contact with the eyes, skin, once the splash on the body, should be immediately washed with a large amount of water.
Last Update：2022-01-01 09:28:54
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Exam
Authoritative Data Verified Data
acidity
take this product, add water to make a solution containing 10 mg per lml, according to the law (General 0631), the pH value should be 4.2~5.2.
phosphite
take about 3.5g of this product, precision weighing, put it in a 250ml iodine bottle, add water to dissolve, add phosphate buffer (pH 7.3)(take sodium dihydrogen phosphate 6.9g, add 500ml of water, shake to dissolve, add 0.lmol/L sodium hydroxide solution 400ml, shake well) 20ml, adjust the pH value with 25% sodium hydroxide solution to 7.3±0.2, precision Iodine titration solution (0.05mol/L)20ml, shake well, close plug, stand in the dark for 3 hours, with 6mol/L acetic acid solution to adjust the pH value to 4.5±0.2, with sodium thiosulfate titration solution (0.lmol/L) titration, when the end point is reached, add 2ml of starch indicator solution, continue titration until the blue color disappears, and correct the titration result with blank test, each 1 ml Iodine titration solution (0.05mol/L) equivalent to 5.199mg of C2H6Na207P2, containing sodium dihydrogen phosphite should not be more than 1.0%.
chloride
take 0.5g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.01% of standard sodium chloride solution, it should not be more concentrated ().
loss on drying
take this product, dry to constant weight at 210°C, weight loss shall not exceed 5.0% (General rule 0831).
Heavy metals
take 0.5g of this product, place it in a quartz crucible, burn it completely, cool it, and check it according to law (General rule 0821 second law). It shall not contain more than 20 parts per million of heavy metals.
Last Update：2022-01-01 13:36:41
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Content determination
Authoritative Data Verified Data
take this product about O.lg, precision weighing, add anhydrous formic acid 2ml, shake, add glacial acetic acid 50ml and acetic anhydride 2ml, shake to dissolve, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 12.50mg of C2H6Na207P2.
Last Update：2022-01-01 13:36:41
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Category
Authoritative Data Verified Data
calcium modulator.
Last Update：2022-01-01 13:36:41
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 13:36:42
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Etidronate Disodium Tablets
Authoritative Data Verified Data
This product contains etidronate disodium (C2H6Na207P2) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.2g of etidronate disodium), add 20ml of water, shake to dissolve etidronate disodium, filter, Take 5ml of filtrate, add 1ml of copper sulfate solution, shake well, after 10 minutes of standing, a blue precipitate was generated.
- take an appropriate amount of fine powder of this product (about 0.2g of etidronate disodium), add 10ml of water, shake to dissolve etidronate disodium, filter, heat and concentrate the filtrate, cool down, and precipitate crystals, the crystals were dried at 105 ° C. For 3 hours and characterized by absorption at 0402cm-1, CM -1, CM -1, CM -1 and CM -1 wave numbers, as determined by infrared spectrophotometry (general).
examination
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 first method), with water as the dissolution medium, the speed is 100 rpm, according to the law, after 30 minutes, take an appropriate amount of the solution, filter, take a precise amount of 2ml of the filtrate, put it in a 10ml measuring flask, then add 2ml of 0.07% copper sulfate solution, dilute it to the scale with water, and shake it well, as a test solution; Another reference substance of etidronate disodium was precision weighed, dissolved with water and quantitatively diluted to prepare solutions containing about 0.12mg, 0.2lmg and 0.24mg respectively per lml, 2ml of each of the above solutions were accurately measured, and then 2ml of 0.07% copper sulfate solution was accurately added, diluted with water to the scale, and shaken to serve as a reference series of solutions; take 2ml of 0.07% copper sulfate solution for precision measurement, put it in a 10ml measuring flask, dilute it with water to the scale, shake it well, and use it as a blank solution. Take the reference series solution according to UV-visible spectrophotometry (General rule 0401 ), at the wavelength of 233nm absorbance, according to the absorbance and concentration, draw the standard curve. Take the sample solution, the same method to determine, calculate the amount of each dissolution. The limit is 85% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine, precision weighing appropriate amount (about equivalent to etidronate disodium 0.lg ), add anhydrous formic acid 2ml and glacial acetic acid 50ml, dissolve, potentiometric titration (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/ L) corresponds to 12.50mg of C2H6Na2O7P2.
specification
0.2g
storage
sealed, stored in dry place ^
Last Update：2022-01-01 13:36:43
disodium dihydrogen (1-hydroxyethylidene)diphosphonate - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | bone resorption inhibitor for primary osteoporosis and postmenopausal osteoporosis. This product is used as food additive |
| production method | The product was obtained by neutralization of hydroxyethylene diphosphate with aqueous sodium hydroxide solution and spray drying. |
Last Update：2024-04-09 20:52:54
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